We propose that this force-dependent regulation of nucleotide exchange is the basic mechanism of gating behaviour — a key regulation for the efficient hand-over-hand movement. The regulatory ...

Point mutations are often thought of as the raw material of evolution; these small changes include the substitution of one nucleotide with another (often referred to as a single-nucleotide ...

In biology we can also find examples of this linkage, as in the human knee joint, where the mechanism allows rotation and keeps the two legs bones attached to each other. It is also present in ...

[Nguyen Duc Thang]’s epic 2100 Animated Mechanical Mechanisms is one of the best YouTube channels we’ve ever seen. A retired mechanical engineer, [Nguyen Duc Thang] has taken on an immense ...

In response to the old question of how the complex brain is formed from a single fertilized egg, and how it comes to exhibit its high-level functions, recent brain research has considerably elucidated ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

Like xeroderma pigmentosum (XP), Cockayne syndrome (CS) is a disease where elements of nucleotide excision repair (NER) do not work properly. The purpose of this repair mechanism is to remove DNA ...

Defense mechanisms are rooted in Freud’s theory of personality.According to his model, the mind has three dueling forces: the id (unconscious and primitive urges for food, comfort, and sex), the ...

For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.

An international team of neuroscientists, led by Duke-NUS Medical School, have uncovered a mechanism that controls the reactivation of neural stem cells, which are crucial for repairing and ...

CRISPR-Cas9 can elegantly and precisely cut away any desired region of DNA and has long been compared to a type of genetic scissors.