Although widely associated with various inflammatory diseases, mast cells have an evolutionarily conserved role in host defence and have been shown to make functional contributions to immunity to ...

Allakos shifted focus to AK006 in 2024 after lirentelimab's failure in phase 2 trials for atopic dermatitis and CSU. Read why ...

In view of today's insights into mast cell pathology, this significance is no longer justified. The occurrence of the phenomena listed as the primary criterion and two secondary criteria seems to ...

Depending on one's perspective, "mast cell activation syndrome (MCAS)" is either a relatively rare, narrowly defined severe allergic condition or a vastly under-recognized underlying cause of ...

Mast cell activation syndrome (MCAS) is a condition in which mast cells—a type of white blood cell that plays a key role in ...

Cell adhesion molecule 1 (CADM1) is one such protein expressed in various cell types, including neurons, respiratory, and endometrial epithelial cells, as well as mast cells. Recently, an antibody ...

A breach in the gut immunity and crossreactivity of the IgE antibodies with skin antigens or direct interaction with specific IgE, Fc receptors on Langerhans cells, mast cells, monocytes ...

AB Science SA, a pharmaceutical company specializing in the research, development and commercialization of protein kinase inhibitors, announced that the European Patent Office has issued a Notice of ...

Ulcerative colitis (UC) is a chronic gut inflammatory condition affecting the colon in humans. This study uses human samples as well as a mouse model of colitis induced by a chemical, DSS, to ...

PRESS RELEASEAB SCIENCE RECEIVES NOTICE OF ALLOWANCE FOR EUROPEAN PATENT COVERING MASITINIB UNTIL 2040 IN THE TREATMENT OF SICKLE CELL DISEASE ...

Dr Chris Jones’ Glioma Group investigates ways to translate basic molecular pathology findings into improved clinical outcomes for children with cancer. The central aim of Professor Kamil Kranc's ...