Kumamoto University researchers identified ATP-citrate lyase (ACLY) as a key enzyme in driving chronic inflammation in aging ...

In a series of in vivo and in vitro studies, the investigators established that astrocyte immune memory is driven by an epigenetic program driven by p300 and ATP-citrate lyase (ACLY)—enzymes that help ...

The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating SASP. This discovery was made using advanced ...

The researchers found that ATP-citrate lyase (ACLY), an enzyme involved in converting citrate to acetyl-CoA, plays a critical role in activating SASP. This discovery was made using advanced ...

Das Enzym Pyruvat-Formiat-Lyase (PFL) katalysiert die Reaktion von Pyruvat zu Acetyl-CoA und Formiat (Anion der Ameisensäure). Es ist Teil des anaeroben Energiestoffwechsels einiger Bakterien wie z.B.

Organomercurial lyase (MerB) catalyzes the difficult cleavage of C-Hg bonds to hydrocarbon and mercuric dithiol products. Model compounds providing two or three thiolate ligands activate ...

Mak's research focuses on the structural characterization of stable terminal states and unstable intermediates involved in the enzymatic cycles of heme proteins that play important roles in human ...

This technology holds the promise of personalized treatments for patients with rare metabolic diseases such as type I citrullinemia, ASA lyase deficiency, and CPS1 deficiency. These life ...

引言棕色脂肪组织（BAT）在哺乳动物能量代谢中扮演着重要角色，尤其在寒冷环境下，它通过非颤栗性产热帮助维持体温。BAT的产热过程由去甲肾上腺素激活，依赖线粒体内膜上的解偶联蛋白1（UCP1），通过消耗线粒体内的电化学质子梯度，将能量转化为热量，从而实 ...

Sandra A. Banta-Wright, MN, RNC, NNP; Robert D. Steiner, MD Neonates with profound and prolonged hyperammonemia with coma due to urea cycle defect will have had a neurological insult to the brain ...

Expert Rev Endocrinol Metab. 2013;8(2):183-193. Mitotane reduces cortisol synthesis through the inhibition of 11B-hydroxylase, 18-hydroxylase, 3-α hydroxylase, hydroxysteroid dehydrogenase and ...