[82] However, the escape of siRNAs from the endosome into the cytosol occurred at low ... nanoparticles in combination with the advantageous effects of various functional lipid components enable ...

In this Thought Leader article., Ian Johnston from Cytiva discusses challenges related to process development, scaling technology, regulatory approvals, and GMP guidelines.

In a recent paper by Nikanjam and colleagues, synthetic low-density lipoprotein-like nanoparticles were prepared from commercial lipids and a bifunctional synthetic peptide containing the low ...

These factors directly influence therapeutic efficacy, immunogenicity ... enables inline monitoring of lipid-based nanoparticles and proteins, at very low turbidity levels that were previously ...

Researchers at the University of Massachusetts Amherst have invented a new, sprayable delivery system for psoriasis ...

In murine models, the platform demonstrated the ability to deliver gene editing systems precisely to the liver while maintaining a low immunogenicity profile. It also has the potential for repeat ...

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune ...

Encapsulated in lipid nanoparticles (LNPs), siRNA can be delivered ... led to a heterogeneous distribution with regions of high and low siRNA concentration. "This heterogeneity can significantly ...

Now, scientists say its ... Ketogenic Diet May Reduce Friendly Gut Bacteria and Raise Cholesterol Levels Aug. 6, 2024 — A study reveals that ketogenic low-carbohydrate diets can increase ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...

High cholesterol increases your risk of cardiovascular conditions like heart disease and stroke. A diet low in saturated fats and high in soluble fiber can help manage your cholesterol levels.