Yet when “naked” RNA is injected, it degrades quickly. To address this issue, scientists have developed, and now widely use, the strategy of encapsulating mRNA into lipid nanoparticles (LNPs).

Charged nanoparticles can alter the local physical properties of lipid membranes, which could shed new light on the interactions between living cells and nanomaterials. An emerging 'rule of thumb ...

LNPs consist of ionizable lipids, which are critical for encapsulating RNA and enabling cellular uptake. Helper lipids contribute to the structural integrity and fusion with cell membranes.

proprietary non-lipid nanoparticle (NLNP) comprising viral glycoproteins. These ChaESAR particles are efficiently taken up by host cells and tissues, where the delivered RNA self-amplifies to make ...

Function-engineerable nanoparticles in combination with the advantageous effects of various functional lipid components enable achievement of enhanced blood stability, decreased toxicity and ...

This is your definitive industry-led meeting to discover new lipid-based nanoparticle formulations and engineer delivery systems for emerging payloads beyond RNA for extrahepatic delivery.

Lipid Nanoparticles (LNPs) are somewhat like liposomes, but more specifically developed to encapsulate various oligonucleotides (RNA and DNA), see Fig. 1c. They are currently the most popular non ...

A new framework bridges a gap in understanding RNA therapeutics by linking the structure of lipid nanoparticles to immune ...

To create nanoparticles that deliver RNA, Whitehead, professor of chemical engineering and biomedical engineering, uses synthetic lipids. They're comprised of carbons and amines, which contain ...

Nanoparticles have once ... and the hydrophilic portions of the lipid components. Accordingly, the LNP formulation is a critical factor linked directly to RNA encapsulation and multiple aspects ...

More information: Xue, L., et al. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular ...

The recent success of the mRNA-LNP vaccines fueled biopharma to explore lipid-based nanoparticles for advanced drug delivery. The industry is now poised to exploit the full therapeutic potential ...