ATP-dependent RNA ligases join 3’-OH and 5’-PO 4 RNA termini via three nucleotidyl transfer steps similar to those of DNA ligases: (Step 1) ligase reacts with ATP to form a covalent ...

ATP-柠檬酸裂解酶（ATP-citrate lyase, ACLY）是脂肪酸合成代谢途径的第一个关键酶，催化底物柠檬酸与CoA形成脂肪酸从头合成所需的二碳单位乙酰辅酶A。

Where most of the industry have programs targeting cereblon, a single E3 ligase that so far has only been demonstrated safe and efficacious in the cancer space, Captor has the tools to explore a ...

However, due to its strong cardiotoxicity, bufalin has limited translational potential. A PROTAC is a heterobifunctional molecule that can bind both a target protein and an E3 ubiquitin ligase to ...

The Centre for Protein Degradation has two main objectives: PROteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules rationally designed to bring the desired target protein in close ...

The regulation of gene expression and signal transduction pathways play a fundamental role in cellular survival and adaptability across all living organisms, from single-celled bacteria to complex ...

Since the expansion, Evotec has significantly scaled up its activities to develop highly promising compounds from Bristol Myers Squibb's industry-leading library of cereblon E3 ligase modulators ...

Place value helps us to work out the value of a digit depending on its place or position in a number. But when we get to nine we run out of numbers. Ah, don't worry little fella. Now we're going ...

"To save succeeding generations from the scourge of war" are among the first very words of the UN Charter (in its Preamble), and those words were the main motivation for creating the United ...

Ah, the adverb train station. If you want to find out about adverbs, there is no better place. An adverb tells you how something happens. Here is a train moving "quickly" on the track. “Quickly ...

Ever glanced at your Android device and noticed a mysterious "N" symbol at the top-right corner of the screen, near the clock ...