Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

These use E3 ubiquitin ligases to promote the degradation of proteins, rather than inhibiting their function like most traditional small molecules. While a focused class of marketed cancer drugs ...

“Using our new ligase enzymes we can produce peptides with promising anti-cancer activity in a single process with excellent yields. Previously, these types of peptides were produced in much lower ...

However, due to its strong cardiotoxicity, bufalin has limited translational potential. A PROTAC is a heterobifunctional molecule that can bind both a target protein and an E3 ubiquitin ligase to ...

(2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc. Natl. Acad. Sci. USA 112, 13868-13873. Unciuleac, M.C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus ...

The Centre for Protein Degradation has two main objectives: PROteolysis Targeting Chimeras (PROTACs) are heterobifunctional molecules rationally designed to bring the desired target protein in close ...

Several enzymes, including DNA polymerase beta, DNA ligases, and DNA endonucleases, depend on magnesium for their optimal activity. Sufficient magnesium levels are necessary for effective DNA ...

However, the power of PROTACs lies in the engagement of E3 ligases, and currently, less than two percent of the vast array of E3 ligases in the human genome have been explored in the TPD field. Dr.

Riley states. However, she acknowledges that they “have yet to identify the E3 ligase(s) responsible for ubiquitinating mutant RIT1. Our CRISPR screen results identified several candidate E3 ligases, ...

Since the expansion, Evotec has significantly scaled up its activities to develop highly promising compounds from Bristol Myers Squibb's industry-leading library of cereblon E3 ligase modulators ...