The paradigm of stellate ... by stellate cells, antagonists have been tested as both antifibrotic and portal hypotensive agents. Alternatively, delivery of NO to injured liver may have the same ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

The HepaStem cells have immunomodulatory properties, similar to other MSCs, and act on the hepatic stellate cells that ... use cells taken from other human donors, not the patient themself ...

Credit: Moscat and Diaz-Meco labs/Provided Low NBR1 levels in hepatic stellate cells enhance interferon signaling in human ...

17 in Molecular Cell, provides new insights into a pair of proteins, called p62 and NBR1, and their opposing functions in regulating the interferon response in hepatic stellate cells, a critical ...

"In contrast to NBR1, if p62 is high in hepatic stellate cells, a patient is protected from cancer, but if it is low, the immune system is knocked down. If NBR1 is high, the immune system is ...

transforming into all the 200 or so kinds of cells that constitute a human body. Liver cells. Brain cells. Skin, bone, and nerve. The dream is to launch a medical revolution in which ailing organs ...

Oct. 31, 2024 — Researchers have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine in human biology. The vast majority of human genes -- more ...

Learn more about the National Academies’ various programs designed to connect, engage, and inspire. In 2005, the National Academies released the book, Guidelines for Human Embryonic Stem Cell Research ...