The inaugural Hippo Pathway Targeted Drug Development ... the mechanistic understanding and potential of the Hippo signaling pathway to enhance the discovery, translation, and clinical development ...

These functions are regulated by the interplay of various signaling pathways. The TGF-β and HIPPO pathways are particularly relevant due to their roles in tumor suppression and liver regulation.

The expansion of the Salvador (SAV)–Warts (WTS)–Hippo (HPO) pathway continues with three recent papers that extend the list of upstream regulators and identify links to Wnt signalling.

This gene is part of the Hippo signaling pathway in the brain. It’s the first time a study associates it with human obesity. The authors found that reducing links in the pathway also ...

The Hippo pathway has been delineated during the past four years (for recent reviews, see refs 3–5).Although primarily worked out in Drosophila, homologues of the pathway components exist in ...

In addition, many major signaling pathways were discovered in fruit flies, including the Hedgehog, Notch and Hippo pathways. In a new study, published in Developmental Cell, Monash University ...

The lab reported in the journal Science that a gene pathway called Hippo inhibits cardiac muscle regeneration during development. View the Science Journal article. Our lab is currently working to ...