Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

The paradigm of stellate ... by stellate cells, antagonists have been tested as both antifibrotic and portal hypotensive agents. Alternatively, delivery of NO to injured liver may have the same ...

The liver is largely comprised of hepatocytes, but Kupffer cells, endothelial cells and hepatic stellate cells are also present.

HHMI researchers solve a longstanding mystery about the origin of new cells in the liver. Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to ...

ACMSD (α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase) is mainly found in the liver and kidneys and is involved in breaking down the amino acid tryptophan and limiting the production of ...

The body's tolerance of lactic acid is limited. Lactic acid is taken to the liver by the blood, and either: oxidised to carbon dioxide and water, or converted to glucose, then glycogen - glycogen ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever ...

According to many experts, we may soon find ourselves using fuel cells to generate electrical power for all sorts of objects we use every day. A fuel cell is a device that uses a source of fuel ...

We're dedicated to conducting cutting-edge, fundamental basic and translational research to improve human health and educating the next generation of scientists. Our faculty, staff, and trainees play ...

Critical assessment of evidence to help you make decisions. Advice, rather than formal NICE guidance.

Mitosis is a type of cell division which produces two identical diploid daughter cells. Cancerous tumours are either malignant or benign. Specialised cells are formed when stem cells differentiate.