We create new chemical and biochemical probes of glycan processing enzymes and use these to evaluate the roles of interesting glycoconjugates in cellular processes and diseases. Cells from all domains ...

Glycans are chains of sugars that attach to cells through proteins or lipids, changing their chemical characteristics. Glycans can be incredibly complex and branched in structure, contributing to ...

Several glycan-masked mutants showed significantly decreased antibody binding to non-CD4bs “off-target” epitopes while maintaining strong binding to CD4bs-specific bnAbs. Furthermore ...

Across the tree of life, cells are coated with sugar chains called glycans that play important roles, acting both as binding sites and nutrients for microbes. By applying advanced methods in ...

By dissecting the role of mucin's protein and glycan components, researchers reveal the complex interactions between diet and gut bacteria, offering insights for future therapeutic applications.