In the outward conformation, the glutamate-binding site is exposed to the extracellular milieu, whereas in the inward conformation, the glutamate-binding site is accessible from the cytoplasm.

Keinanen and colleagues examined the fate of receptors bearing point mutations in this domain (at positions R507 and E727) that directly alter glutamate binding. Using electrophysiology and ...

NMDA receptors are composed of four distinct subunits: two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. These subunits are assembled in a heterotetrameric way to form a ...

He attributed the meaty, savoury taste found in kombu dashi — a traditional Japanese broth made from dried fish known as bonito and dried seaweed — to a chemical called glutamate. Soon after, Dr Ikeda ...

"1-2% of the global population and one in every 36 boys in the U.S. are diagnosed with autism spectrum disorder (ASD), with numbers rising over time." ...