Indeed, this perspective is indispensable for connecting molecular changes at the level of nucleic acids ... and catalysis, this result has clear implications for promiscuity in ancestral enzymes.

Oxygenases have long been thought to require a cofactor for catalysis. The structure of a vancomycin biosynthetic enzyme in complex with a substrate analog, and with molecular oxygen bound in its ...

More information: Victoria A. Maola et al, Directed evolution of a highly efficient TNA polymerase achieved by homologous ...