Studies suggest Tirzepatide may offer a unique combination of GIP sequence modification and GLP-1 receptor agonist action. The goal in developing Tirzepatide was to bind to the GLP-1 receptor around ...

Both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are endogenous physiological substrates for DPP-4, and chemical inhibition of DPP-4 activity ...