The genetic basis of Fanconi anemia (FA) is mysterious and complex, as none of the five genes previously associated with the disorder have homology to genes encoding proteins of known function.

Genes have been identified for many of the inherited syndromes. This article reviews Fanconi's anemia (FA), the most common of the rare inherited bone marrow failure syndromes, and discusses new ...

A macrocytic anemia develops, which usually precedes the onset of thrombocytopenia and neutropenia. Pancytopenia manifests itself at a median age of 7 years.