A research team led by Dr. Du Xuemin from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of ...

Exosomes are very small ... the device can isolate a much larger variety of species of microRNA than conventional ultracentrifugation methods. “By combining the technology with machine-learning ...

Conclusion: The significant difference in total exosome and miRNA levels between lung cancer patients and controls, and the similarity between the circulating exosomal miRNA and the tumor-derived ...

Small RNA was isolated from circulating tumor exosomes using mirVana isolation kit (Ambion, Austin, TX), and this low-molecular-weight RNA–enriched fraction was used for miRNA profiling as ...

exosome天然存在于体液中，且携带重要的信号分子，有望在多种疾病的早期诊断中发挥作用。例如，尿液中的exosomal mRNA和非编码RNA可做为肾脏疾病的生物标志物；脑脊液中的exosomal miRNA有可能作为神经退行性疾病的生物标志物。Exosome在液体活检中的应用意味着这 ...

Researchers use nanowire-based miRNA extraction and machine learning (ML) analysis to detect cancer-associated miRNAs in ...

microRNA detection in very dilute samples (e.g., urine, CSF) can be boosted by first isolating exosomes in the sample and then profiling microRNAs contained in these extracellular vesicles. The gold ...

Cancer has a high death rate with delayed diagnosis of the disease being one of the main reasons for its fatality. Early ...

Led by Shiqi Hu and her team, this research uncovered how exosomes containing specific microRNA regulate a key signaling ...

Another limitation was the lack of an established microRNA control against which to normalize the levels of candidate microRNAs used to develop the signature. An investigational exosome-based ...

The ultracentrifugation technique was further used to compare and validate the efficiency of miRNA capture by nanowires. The results revealed that EVs containing miRNAs, including exosomes-unique ...