Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...

Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

With single-base resolution data, we are able to precisely identify changes at individual gene enhancers, providing a detailed molecular understanding of ... About duet evoC The combinatorial genetic ...

More information: Feng Xiao et al, Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease, Nature Genetics (2024). DOI: 10.1038/s41588-024 ...

Researchers discovered that gene deserts, non-coding DNA regions, regulate heart and embryo development through enhancer ...