In Study II, [16] patients in the duloxetine group who had <30% reduction from baseline in pain severity on the BPI 24-h average pain severity scale, had their dose increased directly to 120 mg ...

Duloxetine acts by increasing the levels of both serotonin and norepinephrine neurotransmitters in the brain, which maintains the mental balance and stops the transmission of pain signals in the ...

Patients were randomized to either 30 mg of duloxetine for 1 week followed ... was a significantly larger decrease in average pain in the duloxetine first group compared with placebo first group ...

Medically reviewed by Mary Choy, PharmDMedically reviewed by Mary Choy, PharmD Cymbalta (duloxetine) and Lexapro ...