The number of possible changes, even within a short region of an antibody, can rapidly become unwieldy, making rational design using site-directed mutagenesis impractical. This is where directed ...

1| In a sterile 0.5-ml microcentrifuge tube or amplification tube (on ice), mix the following reagents for the first amplification reaction: 2| Place the tubes in a thermocycler and amplify the ...

2024年11月11日，来自清华大学的张数一团队在Nature Methods上发表了名为“EvoAI enables extreme compression and reconstruction of the protein sequence space”的文章 蛋白质作为最重要的生命构建单元之一，其序列和功能之间的映射（适应性景观，Fitness landscape）的针对性研究对于 ...

Protein engineering is a powerful biotechnological process that focuses on creating new enzymes or proteins and improving the functions of existing ones by manipulating their natural macromolecular ...

The global synthetic biology market is anticipated to reach USD 31.52 billion in 2029 from USD 12.33 billion in 2024, with a ...

The global synthetic biology market is anticipated to reach USD 31.52 billion in 2029 from USD 12.33 billion in 2024, with a ...

Routine biochemistry studies of catalytic mechanisms, for instance, routine studies using tools such as site-directed mutagenesis, are not typically suitable. We welcome studies that report important ...

引言2024 年第 47 届圣安东尼奥乳腺癌研讨会（San Antonio Breast Cancer Symposium，SABCS）将于 2024 年 12 月 10-13 日在美国圣安东尼奥隆重召开。SABCS 是规模最大的聚焦于乳腺恶性肿瘤的全球盛会，届时，来自世界各地的行业领袖、专家共同探讨乳腺癌领域的最新研究进展。近期，官方已公布大会详细日程，有 20 ...

After postdoctoral work at Ottawa and Princeton, he made his career at the University of Toronto. Michael Smith shared the 1993 Nobel Prize in Chemistry for work on site-directed mutagenesis. In the ...

The Leismhania membrane protein KMP-11 facilitates parasite invasion into macrophages through cholesterol transport from the ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...