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《Nature Biotechnology》宏基因组分析新方法
除了速度外,研究人员还发现,sylph比其他侧写器更精确。研究人员在《Nature Biotechnology》上发表的一篇论文中写道,Sylph的创新“是一种基于零膨胀泊松统计的统计模型,可以在低覆盖率下消除遏制平均核苷酸同一性(ANI),解决低丰度ANI计算问题。”该模型的公式可以按比例调整,使其能够检测到样本中存在的罕见基因组。
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