FMC63, an IgG2a mouse monoclonal antibody, targets CD19. To date, a majority of the reported CART19 trials include the anti-CD19 scFv extracted from FMC63, such as both the FDA-approved CARs ...

To establish whether molecules other than scFv antibody fragments could be lipid-modified and inserted into cell membranes, we cloned the gene encoding human interleukin-2 (IL-2) into vector pLP2 ...

The production capabilities encompass a broad spectrum of antibody formats, including full-length, scFv, Fab, sdAb/VHH, Fc fusion proteins, chimeric antibodies, and bispecific antibodies.

An alternative to antigen-specific expansion is the transduction of patient T cells, usually via lentivirus, with a chimeric antigen receptor (CAR) specific for a tumor antigen. Such receptors are ...