Ovarian tumors are infiltrated by both effector (CD4+CD25-) T cells and by an excess of TREG cells (CD4+CD25+). These TREG cells impede the function of the effectors in combating the tumor.
What Measurable Criteria Can We Set for the Immune Responses Required of a T-cell Vaccine? The evolution of T-cell functional assays over the last 10 years has been phenomenal. [68] There has been ...