Background: High dose (70 to 90 mg/kg/day) amoxicillin is recommended as first line therapy of acute otitis media (AOM) in geographic areas where drug-resistant Streptococcus pneumoniae is prevalent.

The high dose amoxicillin treatment was associated with a high clinical response rate on Days 4 to 6 (94%) and at the end of therapy (93%) and was well-tolerated. Therefore, because its overall ...