AKT signaling pathway is one of the most critical and extensively investigated signaling pathways. It is the central ...
ALTA2618 is the first mutant-selective allosteric inhibitor of AKT1 E17K and is designed to avoid on-target toxicities associated with inhibition of AKT family kinases. AKT1 E17K is a clinically ...
Atavistik Bio Inc. has nominated an orally bioavailable selective allosteric AKT1 E17K inhibitor, ATV-1601, as a development candidate for AKT1 E17K-driven cancers. BioWorld Science Cancer Small ...
This is achieved by the interaction between the potassium ion channel AKT1 and the potassium transporter HAK5. "Although HAK5 has been known since the late 1990s, its transport mechanism has so ...
That may be because the non-biomarker group in the study included quite a high proportion of untested patients in whom PIK3CA/AKT1/PTEN status was unknown. Mutations in PIK3CA, AKT1, and ...
THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...
这是通过钾离子通道AKT1和钾转运体HAK5之间的相互作用实现的。 研究与植物育种有关 德国巴伐利亚州维尔茨堡大学的Rainer Hedrich教授说:“尽管从20世纪90年代末就已经知道了HAK5，但到目前为止 ...
RePlex中的关键步骤是在第一轮探测后能有效去除抗体。因此，评估了针对Jurkat和MCF7裂解物的pan AKT/AKT1/AKT2/phospho AKT1/ phospho AKT2/phospho GSK3b抗体的去除效率。结果显示，所有测试的抗体均显示出 ...
Plants have two separate potassium uptake systems, the transporter HAK5 and the channel AKT1. Depending on the potassium concentration in the soil, one or the other system is responsible for the ...
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