进一步实验发现ApoE聚集体可促进Aβ的形成。 5xFAD小鼠分别在接受人源性ApoE3和ApoE4聚集体后均可促进Aβ的沉积。此外，研究人员将人源性ApoE3和ApoE4 ...

*仅供医学专业人士阅读参考APOE4是阿尔茨海默病（AD）的最强遗传风险因素，降低AD发病年龄，促进AD的典型病理，包括β-淀粉样蛋白（Aβ）和过度磷酸化的tau蛋白（p-tau）沉积。APOE4在AD发病机制中的作用十分复杂，仍没有被完全揭示。星形 ...

AD的典型病理特征是患者大脑中的海马体和皮质出现由难溶的β淀粉样蛋白（Aβ）纤维沉积而形成的老年斑（Aβ plaques），AD病因中最重要也最得到 ...

A collaborative research group has uncovered a new mechanism in the growth of amyloid β (Aβ) fibrils, which are closely associated with Alzheimer's disease. Using advanced high-speed atomic ...

By the early 1990s, the amyloid cascade hypothesis had emerged, proposing that AD is fundamentally caused by deposition of Aβ protein. The cascade component of the hypothesis captures the idea ...

Scientists led by Mikael Simons of the German Center for Neurodegenerative Diseases in Munich report that, within the bowels of microglial lysosomes, ApoE forms fibrillar aggregates alongside Aβ.